[Effect of varicocele on expression of apoptosis associated gene Bcl-2 and Bax in spermatogenic cells of adolescent rats].
Sichuan Da Xue Xue Bao Yi Xue Ban
; 36(4): 497-9, 518, 2005 Jul.
Article
em Zh
| MEDLINE
| ID: mdl-16078570
ABSTRACT
OBJECTIVE:
To study the effect of varicocel (VC) on expression of apoptosis associated gene Bcl-2 and Bax in spermatogenic cells of adolescent rats, and investigate the mechanism of the infertility resulting from varicocele.METHODS:
The varicocele model was created by partial ligation of the left renal vein in the adolescent rats, two and four and eight weeks after creation of the varicocele model, the expressions of Bcl-2 and Bax were detected by immunohistochemical method.RESULTS:
With the duration of varicocele model, the Bcl-2 expression in experiment group was decreased as compared with that in control group. And in experiment group, the Bcl-2 expression level was lower in left testis than in right testis. But Bax expression in experiment group was increased as compared with that in control group, and in experiment group, the Bax expression level was higher in left testis than in right testis.CONCLUSION:
Experimental varicocele could change obviously expression of apoptosis associated gene Bcl-2 and Bax in spermatogenic cells of adolescent rats.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Espermatozoides
/
Varicocele
/
Apoptose
/
Proteínas Proto-Oncogênicas c-bcl-2
/
Proteína X Associada a bcl-2
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2005
Tipo de documento:
Article