Thrombotic thrombocytopaenic purpura in HIV-infected patients.
Int J STD AIDS
; 16(8): 538-42, 2005 Aug.
Article
em En
| MEDLINE
| ID: mdl-16105187
ABSTRACT
Thrombotic thrombocytopaenic purpura (TTP) results from deficiency of von Willebrand factor-cleaving protease (vWF-cp) activity. Eight HIV-infected patients presented with TTP, representing 12.5% of all TTP treated at this centre. In four patients presentation with TTP revealed underlying HIV infection, the other four patients were previously known to be HIV infected, with plasma exchange and highly active antiretroviral therapy (HAART) all recovered. Normalization of vWF-cp activity was associated with recovery. Relapse occurred in two patients who discontinued HAART against medical advice, suggesting that HIV has a causal role in this condition. Given the clear benefit from HAART in addition to plasma exchange, these data suggest that all patients presenting with TTP should undergo HIV testing.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Púrpura Trombocitopênica Trombótica
/
Metaloendopeptidases
/
Infecções por HIV
Limite:
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article