Blink rate in boys with fragile X syndrome: preliminary evidence for altered dopamine function.
J Intellect Disabil Res
; 49(Pt 9): 647-56, 2005 Sep.
Article
em En
| MEDLINE
| ID: mdl-16108982
ABSTRACT
BACKGROUND:
Dopamine, a neurotransmitter involved in motor and cognitive functioning, can be non-invasively measured via observation of spontaneous blink rates. Blink rates have been studied in a number of clinical conditions including schizophrenia, autism, Parkinsons, and attention deficit/hyperactivity disorder with results implicating either hyper or hypo dopaminergic states.METHODS:
This study examined spontaneous blink rate in boys with fragile X syndrome (FXS). Blink rates of boys (4-8 years old) with FXS (n = 6) were compared with those of age-matched typically developing boys (n = 6) during active and passive tasks. Blink rates (blinks per minute) for each task were compared between the two groups. Then, the relation between blink measures and core FXS-related features [problem behaviours, arousal, fmr 1 protein (FMRP)] were examined within the group of boys with FXS.RESULTS:
Blink rate in boys with FXS was significantly higher than typically developing boys during passive tasks. Within the FXS group, there were significant correlations between blink rate and problem behaviours and physiological arousal (i.e. heart activity) but not with FMRP.CONCLUSIONS:
Observed differences in spontaneous blink rate between boys with and without FXS and the relation between blink rate and physiological and behavioural measures in boys with FXS suggests that further work examining dopamine dysfunction as a factor in the pathophysiology of FXS may be warranted.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piscadela
/
Dopamina
/
Síndrome do Cromossomo X Frágil
Limite:
Child
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article