[Determination of antioxidants in plasma and erythrocyte in patients with epilepsy].

ABSTRACT

OBJECTIVE: To explore the changes of antioxidants in plasma and erythrocyte in epileptic patients. METHODS: The levels of erythrocyte enzymes glutathione reductase (GR), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase and erythrocyte membrane lipid peroxidation (MDA), the percentage hemolysis, and plasma ceruloplasmin, vitamin A, vitamin C, vitamin E were measured in 39 controls, 32 epileptic patients and 26 follow-up patients. RESULTS: The levels of MDA, the percentage hemolysis, GSH-Px, CAT and plasma CER in the epileptic patients were significantly higher than those of the controls. While the levels of vitamin A, vitamin C, vitamin E, SOD and GR in the epileptic patients were markedly lower than those of controls. In the follow-up patients, the levels of GR, SOD, vitamin C and vitamin E were significantly higher than those of the epileptic patients. CONCLUSION: Free radicals and antioxidants play important roles in the etiology of epilepsy.