[Effect of ulinastatin on human blood coagulation and platelet aggregation in orthopaedic surgery].

ABSTRACT

OBJECTIVE: To investigate the effect of ulinastatin (UTI) on human blood coagulation and platelet aggregation in orthopaedic surgery. METHODS: Thirty ASA I-II patients without blood dyscrasia and blood coagulation obstacle were randomly divided into two groups Group I (UTI group, n=15) in which patients received UTI 5000 U/kg, and Group II (control group, n=15) in which patients received NS 100 ml. PT, TT, APTT, IB, INR and PAG1, PAG5, and PAGM were measured at 3 points pre-infusion (T0), 1 hour after the infusion (T1), and 2 hours after the infusion (T2). RESULTS: Compared with the saline group, APTT and PT of UTI group were prolonged significantly than the baseline (before infusion). In Group I, after the infusion, APT, TT and PT were prolonged significantly than before the infusion. CONCLUSION: UTI 5000 U/kg can ameliorate orthopaedic patients and blood coagulation status,which may reduce microthrombus syndrome in the operation and prevent venous thrombosis after the operation.