7-hydroxy-3-(4-hydroxybenzyl)chroman and broussonin b: neurotrophic compounds, isolated from Anemarrhena asphodeloides BUNGE, function as proteasome inhibitors.
Biol Pharm Bull
; 28(9): 1798-800, 2005 Sep.
Article
em En
| MEDLINE
| ID: mdl-16141565
ABSTRACT
The extract of Anemarrhenae Rhizoma (rhizomes of Anemarrhena asphodeloides BUNGE) showed neurotrophic activity toward rat pheochromocytoma (PC-12) cells. Bioassay-guided purification afforded four compounds, 2,6,4'-trihydroxy-4-methoxybenzophenone (1), 7-hydroxy-3-(4-hydroxybenzyl)chroman (2), broussonin B (3), and cis-hinokiresinol (4). Compounds 1-3 induced neurite outgrowth in PC-12 cells at concentration of 50 microg/ml, while 4 was less active. In addition, compounds 2-4 showed moderate inhibitory activities against a chymotrypsin-like activity of the proteasome.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenóis
/
Inibidores de Proteases
/
Compostos de Benzil
/
Fármacos do Sistema Nervoso Central
/
Cromanos
/
Anemarrhena
/
Alcanos
/
Sistema Nervoso
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article