An analysis of the binding modes of ATP-competitive CDK2 inhibitors as revealed by X-ray structures of protein-inhibitor complexes.
Curr Med Chem Anticancer Agents
; 5(5): 561-73, 2005 Sep.
Article
em En
| MEDLINE
| ID: mdl-16178778
ABSTRACT
CDK2 is an attractive target for the design of new therapeutic antitumor agent. Numerous CDK2 inhibitors have been discovered and their crystallographic structures either in complex with CDK2 or CDK2/Cyclin A have been published. This review aims to summarize the publicly available structural characterization of CDK2/(Cyclin A) -- ligand complexes and to highlight the similarities among the binding modes of structurally diverse inhibitors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trifosfato de Adenosina
/
Quinases relacionadas a CDC2 e CDC28
/
Inibidores Enzimáticos
Limite:
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article