Your browser doesn't support javascript.
loading
Evaluation of cytokine polymorphisms (TNFalpha, IFNgamma and IL-10) in Down patients with coeliac disease.
Cataldo, F; Scola, L; Piccione, M; Giuffrè, M; Crivello, A; Forte, G I; Lio, D; Corsello, G.
Afiliação
  • Cataldo F; Department of Pediatrics, University of Palermo, Italy. cescocat@freemail.it
Dig Liver Dis ; 37(12): 923-7, 2005 Dec.
Article em En | MEDLINE | ID: mdl-16182624
BACKGROUND: In Down syndrome there is an increased prevalence of coeliac disease, but the reasons for this association are yet unknown. AIMS: To evaluate a possible correlation between TNFalpha, IFNgamma and IL-10 genotype polymorphisms with the susceptibility to coeliac disease in Down syndrome patients. METHODS: Single nucleotide polymorphisms of TNFalpha (-308G-->A promoter region), IFNgamma (+874T-->A promoter region) and IL-10 (-1082G-->A promoter region) have been studied in 10 Down patients with coeliac disease, in 40 Down patients without coeliac disease and in 220 healthy controls. Clinical features were also studied in coeliac disease-Down syndrome patients. RESULTS: The 10 coeliac disease-Down syndrome patients had a biopsy proven coeliac disease afterward a serological testing positive to antigliadin, antiendomysium and antitransglutaminase antibodies. Intestinal biopsy showed total atrophy in 6/10 and partial villous atrophy in 4/10 of them. All coeliac disease-Down syndrome patients had silent forms of coeliac disease and classical trisomy 21. No significant differences were observed for the IFNgamma and IL-10 polymorphisms in the studied groups. A significant trend for increase of TNFalpha -308A positive frequency was observed in coeliac disease-Down syndrome patients compared to healthy controls (p=0.043). CONCLUSIONS: Single nucleotide polymorphisms of IFNgamma and IL-10 do not play a role in predisposing Down syndrome patients to coeliac disease, while the TNFalpha -308 allele could be an additional genetic risk factor for coeliac disease in trisomy 21.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença Celíaca / Interferon gama / Fator de Necrose Tumoral alfa / Interleucina-10 / Síndrome de Down Tipo de estudo: Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Humans / Infant Idioma: En Ano de publicação: 2005 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença Celíaca / Interferon gama / Fator de Necrose Tumoral alfa / Interleucina-10 / Síndrome de Down Tipo de estudo: Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Humans / Infant Idioma: En Ano de publicação: 2005 Tipo de documento: Article