Novel 5beta-hydroxyspirostan-6-ones ecdysteroid antagonists: synthesis and biological testing.
Steroids
; 71(1): 1-11, 2006 Jan.
Article
em En
| MEDLINE
| ID: mdl-16191434
ABSTRACT
Eight new 5beta-hydroxy-spirostan-6-ones bearing hydroxy and amino functions in the A ring, i.e., 3beta-OH, 3alpha-OH, 2beta,3beta-OH, 2alpha,3beta-OH, 3beta-NH2, 2alpha-NH2-3beta-OH, 2beta-NH2-3beta-OH, and 2beta-OH-3beta-NH2, were efficiently synthesized, and their antiecdysteroid activities were evaluated on the metamorphosis bioassay of mosquito Aedes aegypti. To our knowledge, these new steroids represent the first 5beta-hydroxy-spirostanes which have been tested for antiecdysteroid activity in mosquitoes. The higher antagonistic effect was found for compounds bearing the 3beta-hydroxy and 2beta,3beta-dihydroxy functionality, which show promise as environmental friendly insecticides.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Espirostanos
/
Aedes
/
Ecdisteroides
/
Inseticidas
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article