Organocatalytic asymmetric alpha-bromination of aldehydes and ketones.
Chem Commun (Camb)
; (38): 4821-3, 2005 Oct 14.
Article
em En
| MEDLINE
| ID: mdl-16193126
ABSTRACT
The first organocatalytic enantioselective alpha-bromination of aldehydes and ketones is presented; a C2-symmetric diphenylpyrrolidine catalyst afforded the alpha-brominated aldehydes in good yields and up to 96% ee, while ketones were alpha-brominated by a C2-symmetric imidazolidine in up to 94% ee; furthermore, the organocatalytic enantioselective alpha-iodination of aldehydes is also demonstrated to proceed with up to 89% ee.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirrolidinas
/
Bromo
/
Imidazolidinas
/
Aldeídos
/
Cetonas
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article