A case for chaperones in antigen processing.
Immunol Today
; 13(3): 86-9, 1992 Mar.
Article
em En
| MEDLINE
| ID: mdl-1622544
ABSTRACT
The assembly of peptide-MHC-class-II molecule complexes by antigen-presenting cells is far more efficient than would be predicted from studies of peptide binding to purified MHC class II molecules in vitro. One possible explanation for this discrepancy is that proteins in the antigen-presenting cell facilitate the assembly process. Here, Diane DeNagel and Susan Pierce present the case for involvement of members of the chaperone/heat shock protein 70 family in the intracellular assembly of processed-antigen-MHC-class-II-molecule complexes.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Choque Térmico
/
Células Apresentadoras de Antígenos
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article