Transdermal sustained-delivery oxygen improves epithelial healing in a rabbit ear wound model.
Arch Surg
; 140(10): 998-1004, 2005 Oct.
Article
em En
| MEDLINE
| ID: mdl-16230552
ABSTRACT
HYPOTHESIS:
Transdermal sustained-delivery oxygen therapy improves wound healing.DESIGN:
Experimental study using a well-established rabbit ear model for acute wound healing.SETTING:
Wound-healing research laboratory in a university center.METHODS:
Four full-thickness 7-mm punch wounds were created on each ear of young, female New Zealand white rabbits. Treated ears received transdermal sustained delivery of oxygen via silicone tubing tunneled subcutaneously to a pocket under a semiocclusive dressing. Oxygen production (100% oxygen at 3 mL/h continuously) relied on a small, self-contained device connected to the silicone tubing and secured to the rabbit's back for the duration of the experiment using a body harness. Ears were harvested at each of 2 time points day 5 and day 8.RESULTS:
Histologic analysis of the wounds showed significantly greater healing at both day 5 and day 8 in response to oxygen therapy. Most significantly, epithelial wound coverage was almost doubled in treated ear wounds when compared with controls.CONCLUSION:
Our results suggest that epithelial wound healing is improved by transdermal sustained-delivery treatment with 100% oxygen.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Ferimentos e Lesões
/
Orelha
/
Gases
/
Isquemia
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article