[The diagnostic value of telomerase activity in differentiating benign and malignant ascitic fluid].
Zhonghua Nei Ke Za Zhi
; 44(10): 745-7, 2005 Oct.
Article
em Zh
| MEDLINE
| ID: mdl-16255881
ABSTRACT
OBJECTIVE:
To investigate the changes of telomerase activity in benign and malignant ascites fluid.METHODS:
The technique of telomerase TRAP-PCR-ELISA was employed to detect telomerase activity in ascites cells from 60 patients with benign or malignant ascites fluid, the cytological diagnosis and total tumor marks (carcinoembryonic antigen, et al.) were compared.RESULTS:
Telomerase activity in malignant ascites fluid was significantly higher than that in benign group. Positive rate of telomerase activity detected in malignant ascites (90%) was remarkably higher than those in benign group (10%); Compared with the cytological diagnosis and total tumor marks (carcinoembryonic antigen, et al.), telomere ferment test had higher sensitivity (90%), specificity (100%) and stability.CONCLUSION:
Telomerase activity may be an useful and sensitive mark in differential diagnosis of benign and malignant ascites fluid.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ascite
/
Telomerase
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Ano de publicação:
2005
Tipo de documento:
Article