Autoantibodies in scleroderma.
Rheum Dis Clin North Am
; 18(2): 483-98, 1992 May.
Article
em En
| MEDLINE
| ID: mdl-1626078
ABSTRACT
The antinuclear and antinucleolar antibodies found in patients with scleroderma are discussed. Many of the autoantigens have been characterized, the cDNA cloned and the epitopes defined. Many of the more common autoantigens are DNA-binding proteins, which are very important in transcription and in cell division. The clinical significance of the autoantibodies is discussed their prevalence and their relation to disease manifestations and prognosis is examined. The unique exclusiveness of the major autoantibodies is discussed. The data on the immunoglobulin and IgG subclass is reviewed in relation to the overall concept that most autoantibodies in scleroderma patients represent the result of an antigen-driven response.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Escleroderma Sistêmico
/
Autoanticorpos
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article