Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor.
Nat Med
; 11(12): 1293-4, 2005 Dec.
Article
em En
| MEDLINE
| ID: mdl-16273102
ABSTRACT
Pre-exposure oral prophylaxis with antiviral drugs is a potential method for preventing transmission of human immunodeficiency virus type 1 (HIV-1). We show that oral delivery of CMPD167, a small molecule that binds to the CCR5 coreceptor, for 10-14 d can protect a substantial proportion of macaques from vaginal infection with a CCR5-using virus (SHIV-162P3). The macaques that became infected despite receiving CMPD167 had reduced plasma viremia levels during the earliest stages of infection.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirazóis
/
Vagina
/
Valina
/
Síndrome de Imunodeficiência Adquirida dos Símios
/
Vírus da Imunodeficiência Símia
/
Antagonistas dos Receptores CCR5
/
Macaca
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article