5-heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure-activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and orally active analog.
Bioorg Med Chem Lett
; 16(2): 288-92, 2006 Jan 15.
Article
em En
| MEDLINE
| ID: mdl-16275075
ABSTRACT
Structure-activity relationship (SAR) studies of the novel 2-[3-di and trifluoromethyl-5-alkylamino pyrazo-1-yl]-5-methanesulfonyl (SO(2)Me)/sulfamoyl (SO(2)NH(2))-pyridine derivatives for canine COX enzymes are described. The studies led to the identification of 2e as lead with potent in vitro activity, selectivity, and in vivo activity in dogs and cats.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirazóis
/
Ciclo-Oxigenase 2
/
Inibidores de Ciclo-Oxigenase 2
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article