The transduction of the nitrogen regulation signal in Saccharomyces cerevisiae.
Proc Natl Acad Sci U S A
; 102(46): 16537-8, 2005 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-16275904
ABSTRACT
In cells of Saccharomyces cerevisiae, using ammonia as a source of nitrogen, Gln3p is sequestered in the cytoplasm by Ure2p but enters the nucleus when the cells are shifted to a nonpreferred source of nitrogen such as proline. The interpretation of recently published observations provides evidence for the view that Ure2p is the sensor for a drop in the intracellular concentration of glutamine, a signal that results in the polyubiquitination of the vesicle responsible for retaining the Gln3p-Ure2p complex in the cytoplasm. As a consequence of the drop in glutamine concentration, Gln3p is able to enter the nucleus and to activate the transcription of nitrogen-regulated genes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
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Saccharomyces cerevisiae
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Fatores de Transcrição
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Transdução de Sinais
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Proteínas de Saccharomyces cerevisiae
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Nitrogênio
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article