Synthesis and structure-activity relationships of novel dipeptides and reduced dipeptides as ligands for melanocortin subtype-4 receptor.
Bioorg Med Chem Lett
; 16(9): 2341-6, 2006 May 01.
Article
em En
| MEDLINE
| ID: mdl-16297618
ABSTRACT
A series of benzylic piperazines (e.g., 4 and 5) attached to an 'address element', the dipeptide H-D-Tic-D-p-Cl-Phe-OH, 3 has been identified as ligands for the melanocortin subtype-4 receptor (MC4R). We describe herein the structure-activity relationship (SAR) studies on the N-terminal residue of the 'address element'. Several novel dipeptides and reduced dipeptides with high MC4R binding affinities and selectivity emerged from this SAR study.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptor Tipo 4 de Melanocortina
/
Dipeptídeos
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article