Adhesion molecules in human dendritic cells.
Curr Opin Investig Drugs
; 6(11): 1103-11, 2005 Nov.
Article
em En
| MEDLINE
| ID: mdl-16312130
ABSTRACT
Dendritic cells are bone marrow-derived professional antigen-presenting cells that link innate and adaptive immunity, and they are essentially involved in the initiation of primary immune responses and in the establishment of peripheral tolerance. The existence of distinct functional states and subsets of dendritic cells is critical for the generation of pathogen-specific immune responses without the risk of autoimmunity or chronic inflammation. To fulfil their effector tasks in tissues and lymph nodes, dendritic cells must engage in multiple adhesive and migratory events. The molecular dissection of these adhesive interactions may provide new potential therapeutic targets to modulate immune responses and to improve current dendritic cell-based therapeutic cancer vaccines.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
/
Moléculas de Adesão Celular
/
Comunicação Celular
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article