In situ fabrication of three-dimensional chemical patterns in fused silica separation capillaries with polymerized phospholipids.
J Am Chem Soc
; 127(48): 16756-7, 2005 Dec 07.
Article
em En
| MEDLINE
| ID: mdl-16316200
ABSTRACT
We report a new molecular approach for in situ generation of micron scale, chemically and biochemically functionalized patterns inside three-dimensional, completely enclosed fluidic channels. The formation of chemical patterns is based upon a combination of lipid bilayer self-assembly and UV photopolymerization of photoreactive, cross-linkable phospholipids. Using this approach, we have functionalized capillaries of varying inner diameters with a range of chemistries useful for protein and peptide immobilization. Here, we demonstrate the ability to produce small molecule and protein-based chemical patterns.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfatidilcolinas
/
Fosfolipídeos
/
Dióxido de Silício
/
Bicamadas Lipídicas
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article