Cytoskeleton and cell cycle control during meiotic maturation of the mouse oocyte: integrating time and space.
Reproduction
; 130(6): 801-11, 2005 Dec.
Article
em En
| MEDLINE
| ID: mdl-16322540
During meiotic maturation of mammalian oocytes, two successive divisions occur without an intermediate phase of DNA replication, so that haploid gametes are produced. Moreover, these two divisions are asymmetric, to ensure that most of the maternal stores are retained within the oocyte. This leads to the formation of daughter cells with different sizes: the large oocyte and the small polar bodies. All these events are dependent upon the dynamic changes in the organization of the oocyte cytoskeleton (microtubules and microfilaments) and are highly regulated in time and space. We review here the current knowledge of the interplay between the cytoskeleton and the cell cycle machinery in mouse oocytes, with an emphasis on the two major activities that control meiotic maturation in vertebrates, MPF (Maturation promoting factor) and CSF (Cytostatic factor).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oócitos
/
Oogênese
/
Citoesqueleto
/
Ciclo Celular
/
Meiose
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article