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[Evaluation on the safety and immunogenicity of Canada split influenza virus vaccine].
Hu, Yue-mei; Fang, Han-hua; Gao, Gui-hua; Zhang, Xue-feng; Zhang, Yi-ju; Zhu, Shi-wei; Zhu, Feng-cai.
Afiliação
  • Hu YM; Jiangsu Provincial Center of Disease Control and Prevention, Nanjing 210009, China.
Zhonghua Liu Xing Bing Xue Za Zhi ; 26(7): 503-6, 2005 Jul.
Article em Zh | MEDLINE | ID: mdl-16335001
OBJECTIVE: To evaluate the safety and immunogenicity of Canada split influenza virus vaccine. METHODS: Cluster samples were by randomly chosen and divided into split vaccination group and homoimported influenza vaccination group. RESULTS: After injection, fever-reaction and local reaction rates of 'trial' group were found as 3.69% and 1.75% respectively, but no statistical significance was found when compared with 'control' group. However the antibody positive rates of 'trail' and 'control' groupsappeared statistically significant (H1N1: 96.8% vs. 92.3%, H3N2: 95.8% vs. 90.2%, B: 52.3% vs. 62.3%). For geometric mean titer (GMT) of type H1N1, H3H2 and B antibody, 'trial' group and 'control' group increased 22.4, 16.8, 8.2 and 21.2, 12.5 and 7.4 times respectively. The antibody protective rates of type H1N1, H3N2 and B were 99%, 99% and 53.9% for 'trial' group, and 96.2%, 98.4% and 62.3% for 'control' but with no statistically significant difference. CONCLUSION: Influenza split vaccine made in Shire company in Canada was safe and with good immunogenicity.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Orthomyxoviridae / Vacinas Virais / Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged País/Região como assunto: America do norte Idioma: Zh Ano de publicação: 2005 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Orthomyxoviridae / Vacinas Virais / Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged País/Região como assunto: America do norte Idioma: Zh Ano de publicação: 2005 Tipo de documento: Article