Simultaneous control of third-degree graft-versus-host disease and prevention of recurrence of juvenile myelomonocytic leukemia (JMML) with 6-mercaptopurine following fulminant JMML relapse early after KIR-mismatched bone marrow transplantation.
J Pediatr Hematol Oncol
; 27(12): 672-4, 2005 Dec.
Article
em En
| MEDLINE
| ID: mdl-16344675
ABSTRACT
The authors describe a young boy with juvenile myelomonocytic leukemia (JMML) who relapsed 45 days after HLA and killer immunoglobulin-like receptor (KIR) mismatched unrelated donor bone marrow transplant (MMUD-BMT) and subsequently developed life-threatening graft-versus-host disease (GvHD). Treatment with 6-mercaptopurine (6-MP) appeared to control severe GvHD and possibly prevented recurrence of leukemic relapse.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores Imunológicos
/
Leucemia Mielomonocítica Aguda
/
Transplante de Células-Tronco Hematopoéticas
/
Doença Enxerto-Hospedeiro
/
Histocompatibilidade
/
Mercaptopurina
/
Antimetabólitos Antineoplásicos
Limite:
Humans
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Infant
/
Male
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article