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Insulin-like growth factor binding proteins in development.
Silha, Josef V; Murphy, Liam J.
Afiliação
  • Silha JV; Department of Physiology, University of Manitoba, Winnipeg, Canada.
Adv Exp Med Biol ; 567: 55-89, 2005.
Article em En | MEDLINE | ID: mdl-16370136
IGFBPs regulate growth and development by regulating IGF transport to tissues and IGF bioavailability to IGF receptors at cell membrane level. IGFBP excess leads predominantly to inhibition of IGF action and growth retardation with impaired organogenesis. Absence of human and also mouse ALS leads to decreased IGF-I levels in circulation and causes mild growth retardation. Although IGFBP KO mice demonstrate relatively minor phenotypes, the possibility of compensatory mechanisms that mask the phenotypic manifestation of lack of individual binding proteins needs to be further investigated. Recent studies of hepatic regeneration in IGFBP-1 KO mice and also with mutant IGFBP-3 Tg mice provide some limited support for the existence of IGF-independent mechanism of action in vivo.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Ligação a Fator de Crescimento Semelhante a Insulina / Embrião de Mamíferos Limite: Animals / Humans Idioma: En Ano de publicação: 2005 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Ligação a Fator de Crescimento Semelhante a Insulina / Embrião de Mamíferos Limite: Animals / Humans Idioma: En Ano de publicação: 2005 Tipo de documento: Article