Behavioral alterations in Lewis rats following two-day continuous 3-nitropropionic acid administration.
Neurotox Res
; 8(3-4): 259-66, 2005 Nov.
Article
em En
| MEDLINE
| ID: mdl-16371320
ABSTRACT
The mitochondrial toxin, 3-nitropropionic acid (3-NP), produces motor dysfunction and striatal atrophy in rats. However, rat strain and method of administration may contribute to variability in the deficits caused by 3-NP toxicity. To evaluate this, changes in nocturnal spontaneous locomotor activity from chronic administration of 3-NP using an osmotic mini pump, were examined in the Lewis rats. Lewis rats were treated with 3-NP or saline for 2 days and behavior was tested daily for a 15 day period. Animals receiving 3-NP displayed significantly less spontaneous activity than animals in the saline group. 3-NP treated animals also weighed significantly less when compared to saline treated animals. These results demonstrate that even though there were no significant alterations in overt anatomical pathology, even short-term exposure to 3-NP produced significant effects. This short-term administration may present a potential paradigm for examination of sub-threshold neurotoxicity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Propionatos
/
Comportamento Animal
/
Convulsivantes
/
Nitrocompostos
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article