Evaluation of nailfold videocapillaroscopic abnormalities in patients with systemic lupus erythematosus.
J Clin Rheumatol
; 11(6): 295-8, 2005 Dec.
Article
em En
| MEDLINE
| ID: mdl-16371797
ABSTRACT
OBJECTIVE:
Nailfold capillaroscopy (NFC) has been shown to have a remarkable value in the differential diagnosis of connective tissue diseases. In fact, NFC patterns reflect the microvascular changes that may play a significant role in pathogenesis. The aims of this study were to determine in patients with systemic lupus erythematosus (SLE) the prevalence of NFC patterns, to evaluate any association with clinical features and laboratory parameters. MATERIALS ANDMETHODS:
One hundred twenty-three patients with SLE were included in this retrospective study. Video NFC parameters were analyzed in each patient. In all cases, the following parameters were evaluated capillary arrangement, density, size, and shape.RESULTS:
In patients with SLE, major capillary abnormalities were frequently observed (44 of 123 = 35.8%); however, no specific pattern was noted. There was a significant correlation between the SLEDAI index and the severity of capillary abnormalities (P < 0.0001). Pathologic capillary abnormalities were also significantly increased in SLE with positive anti-U1-RNP antibodies (P < 0.05).CONCLUSION:
NFC may be a useful method to evaluate the microvascular changes in patients with SLE, and the presence of major capillary abnormalities seems to herald a more severe clinical course of the illness.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gravação em Vídeo
/
Capilares
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Angioscopia Microscópica
/
Lúpus Eritematoso Sistêmico
/
Unhas
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Child
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Child, preschool
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article