Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival.
Mol Cell Biol
; 26(2): 699-708, 2006 Jan.
Article
em En
| MEDLINE
| ID: mdl-16382159
ABSTRACT
The cellular inhibitor of apoptosis 2 (cIAP2/HIAP1) is a potent inhibitor of apoptotic death. In contrast to the other members of the IAP family, cIAP2 is transcriptionally inducible by nuclear factor-kappaB in response to multiple triggers. We demonstrate here that cIAP2-/- mice exhibit profound resistance to lipopolysaccharide (LPS)-induced sepsis, specifically because of an attenuated inflammatory response. We show that LPS potently upregulates cIAP2 in macrophages and that cIAP2-/- macrophages are highly susceptible to apoptosis in a LPS-induced proinflammatory environment. Hence, cIAP2 is critical in the maintenance of a normal innate immune inflammatory response.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apoptose
/
Sepse
/
Proteínas Inibidoras de Apoptose
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Macrófagos
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article