Depeptidization efforts on P3-P2' alpha-ketoamide inhibitors of HCV NS3-4A serine protease: effect on HCV replicon activity.
Bioorg Med Chem Lett
; 16(6): 1621-7, 2006 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-16387495
ABSTRACT
Depeptidization efforts of the P(3)-P(2) region of P(3) capped alpha-ketoamide inhibitor of HCV NS3 serine protease 1 are reported. We clearly established that N-methylation of the P(2) nitrogen and modification of the P(2)' carboxylic acid terminus were essential for activity in the replicon assay.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Replicon
/
Inibidores de Serina Proteinase
/
Proteínas não Estruturais Virais
/
Hepacivirus
/
Amidas
/
Nitrogênio
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article