Building addressable libraries: spatially isolated, chip-based reductive amination reactions.
J Am Chem Soc
; 128(1): 70-1, 2006 Jan 11.
Article
em En
| MEDLINE
| ID: mdl-16390126
ABSTRACT
A Pd(II) reagent has been generated at preselected sites on an electrochemically addressable chip and used to effect the oxidation of the neighboring alcohols on the polymer coating the chip's surface. The resulting carbonyls were then used to accomplish site-selective reductive amination reactions on the chips. The work demonstrates that the confinement strategy developed for spatially isolated Wacker oxidations to specific sites on the chips is general and can be used for other Pd(II)-based reactions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Semicondutores
/
Aminas
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article