Influence of cigarette smoke on the L-ascorbic acid metabolism and the activities of drug-metabolizing enzyme in rats.
J Nutr Sci Vitaminol (Tokyo)
; 51(5): 374-6, 2005 Oct.
Article
em En
| MEDLINE
| ID: mdl-16392710
ABSTRACT
This study clarified the influence of cigarette smoke on the L-ascorbic acid (AsA) metabolism and the activities of drug-metabolizing enzyme in rats. The test rats (group T) were exposed to weak sidestream smoke from cigarettes for 2 h, everyday for 57 days. AsA concentration in the tissues and excreted amount of AsA in urine of group T tended to be higher than those of control group (group C). The plasma AsA concentration and the activities of aniline hydroxylase and 7-ethoxycoumarin O-deethylase of group T were significantly higher than those of group C. There was no significant difference in the activity of UDP glucuronosyltransferase or in the liver cytochrome P-450 content between these two groups.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Ascórbico
/
Poluição por Fumaça de Tabaco
/
Anilina Hidroxilase
/
O-Dealquilase 7-Alcoxicumarina
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article