[The expression of Maspin and VEGF gene in oral squamous cell carcinoma and its significance].
Shanghai Kou Qiang Yi Xue
; 14(6): 557-60, 2005 Dec.
Article
em Zh
| MEDLINE
| ID: mdl-16400477
ABSTRACT
PURPOSE:
To study the expression of Maspin(marray serine proteinase inhibitor) and VEGF(vascular endothelial growth factor) gene in oral squamous cell cancers(OSCC) and the relationship between Maspin and VEGF.METHODS:
mRNA expression of Maspin and VEGF gene was investigated by RT-PCR in every samples of 18 OSCC cases. F test and Person test were used for data analysis.RESULTS:
mRNA expression of Maspin gene increased gradually in OSCC, paratumor and normal epithelium(P<0.01); mRNA expression of VEGF gene decreased gradually in OSCC,paratumor and normal epithelium(P<0.01); The expression of Maspin and VEGF gene was negatively correlated in OSCC(P<0.01) ; The expression of Maspin gene was negatively associated but VEGF gene was positively associated with lymph node metastasis in OSCC(P<0.05); The expression of Maspin and VEGF gene had no relation with the histological grade or tumor size in OSCC.CONCLUSION:
Maspin and VEGF gene may play an important role in the development of OSCC and Maspin gene may down-regulate the expression of VEGF gene.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Bucais
/
Carcinoma de Células Escamosas
/
Serpinas
/
Fator A de Crescimento do Endotélio Vascular
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2005
Tipo de documento:
Article