Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids.
J Med Chem
; 49(2): 456-8, 2006 Jan 26.
Article
em En
| MEDLINE
| ID: mdl-16420030
ABSTRACT
The synthesis and matrix metalloproteinase (MMP) inhibitory activity of a series of gamma-keto carboxylic acids are described. Among nine MMP isozymes tested, compound 1j displays selective inhibition of MMP-2, -9, and -12 with IC(50) values between 0.20 and 1.51 microuM, and in male golden Syrian hamsters, it shows protection against PPE-induced emphysema.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Enfisema Pulmonar
/
Inibidores de Metaloproteinases de Matriz
/
Cetoácidos
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article