Tetrahydro-6-biopterin is associated with tetrahydro-7-biopterin in primary murine mast cells.
FEBS Lett
; 307(2): 147-50, 1992 Jul 28.
Article
em En
| MEDLINE
| ID: mdl-1644167
ABSTRACT
Murine bone marrow-derived mast cells proliferate in response to interleukin 3. In addition to 6-biopterin, 7-biopterin was identified in these cells by HPLC analysis of iodine oxidized extracts and by alkaline permanganate oxidation to the 6- and 7-carboxylic acids. 7-Biopterin comprised 31.9 (+/- 7.7)% of the total biopterin. It was absent in cells which were grown with of L-p-chlorophenylalanine, an inhibitor of tryptophan 5-mono-oxygenase. Both 6- and 7-biopterin were present in the cell as their tetrahydro forms. From these data we conclude that 7-biopterin, in contrast to e.g. brain tissue, regularly occurs as a normal metabolite in primary mast cells and that it is generated during hydroxylation of tryptophan.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biopterinas
/
Mastócitos
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article