Nitrones as therapeutics in age-related diseases.
Aging Cell
; 5(1): 51-7, 2006 Feb.
Article
em En
| MEDLINE
| ID: mdl-16441843
ABSTRACT
Age-related diseases deprive individuals of a higher quality of life and therefore therapeutics for their treatment provide significant potential. An overview of the observations of nitrones as potential therapeutics in several age-related diseases is presented. Treatment of acute ischemic stroke is one condition where a nitrone (NXY-059) is in late phase 3 clinical trials now. Also presented is a summary of the most recent work we have accomplished on the anticancer activity of the nitrones in a hepatocellular carcinoma. The mechanistic basis of action of these compounds in several animal models is not yet understood at the molecular levels; however, it does appear clear that their anti-inflammatory properties are central to their action, which is based on their ability to down-regulate exacerbated signal transduction processes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Óxidos de Nitrogênio
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article