An alpha-1 chain of type I collagen Sp1-binding site polymorphism in women suffering from stress urinary incontinence.
Am J Obstet Gynecol
; 194(2): 346-50, 2006 Feb.
Article
em En
| MEDLINE
| ID: mdl-16458627
ABSTRACT
OBJECTIVE:
We examined the possible influence of G-->T substitution in transcription factor Sp1-binding site in the gene encoding alpha-1 chain of type I collagen on the risk of stress urinary incontinence. STUDYDESIGN:
The study group consisted of 50 women reporting symptoms of stress urinary incontinence. Fifty control subjects were treated for benign gynecological conditions other then stress urinary incontinence. DNA was obtained from peripheral blood leukocytes. The fragment of the first intron of the gene encoding the alpha-1 chain of type I collagen containing the Sp1-binding site was amplified by polymerase chain reaction. The analysis of restriction fragment length polymorphism was performed.RESULTS:
We found association between the GT and TT genotype and stress urinary incontinence (P = .019). The odds ratio for developing stress urinary incontinence is 4.98 (95% confidence interval 1.97 to 12.56) in subjects presenting the GT genotype and 2.23 (95% confidence interval 0.69 to 7.25) for the TT genotype.CONCLUSION:
The G-T polymorphism at the Sp1 binding site of the gene encoding alpha-1 chain of type 1 collagen is associated with increased risk of stress urinary incontinence in women.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Incontinência Urinária por Estresse
/
Fator de Transcrição Sp1
/
Colágeno Tipo I
Limite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article