Synthesis and evaluation of novel heterocyclic inhibitors of GSK-3.
Bioorg Med Chem Lett
; 16(8): 2091-4, 2006 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-16460937
ABSTRACT
A set of novel heterocyclic pyrimidyl hydrazones has been synthesized as inhibitors of glycogen synthase kinase-3 (GSK-3) with the most active exhibiting low nanomolar activity. Quantum mechanical calculations indicate that of the conformational factors that could determine binding affinity, the planarity of the phenyl ring in relation to the central core and the conformation of the hydrazone chain may be the most influential.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quinase 3 da Glicogênio Sintase
/
Inibidores Enzimáticos
/
Compostos Heterocíclicos
Tipo de estudo:
Evaluation_studies
/
Prognostic_studies
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article