Sprouty and cancer: the first terms report.
Cancer Lett
; 242(2): 141-50, 2006 Oct 28.
Article
em En
| MEDLINE
| ID: mdl-16469433
ABSTRACT
The Ras/Erk signaling pathway has a central role in development of multi-cellular organisms as well as in signal transmission in the mature individual. Recently, a family of genes, designated Sprouty, induced by the Ras/Erk pathway was found to specify proteins that inhibited the upstream pathway. Being in a position that is likely to control well-characterized oncogene products suggested that the expression levels of the Sprouty genes may be relevant in human carcinogenesis. Early data on the deregulation of Sprouty expression in breast, prostate and liver cancers is discussed along with the notion that some of them might have potential as tumour markers or that the derived proteins may act as tumour suppressors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfoproteínas
/
Neoplasias da Próstata
/
Neoplasias da Mama
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Regulação Neoplásica da Expressão Gênica
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Neoplasias Hepáticas
/
Proteínas de Membrana
Limite:
Animals
/
Female
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Humans
/
Male
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article