Your browser doesn't support javascript.
loading
Effects of claritromycin on inflammatory parameters and clinical conditions in children with bronchiectasis.
Yalçin, E; Kiper, N; Ozçelik, U; Dogru, D; Firat, P; Sahin, A; Ariyürek, M; Mocan, G; Gürcan, N; Göçmen, A.
Afiliação
  • Yalçin E; Chest Diseases Unit, Department of Pediatrics, Hacettepe University Faculty of Medicine, 06100-Ankara, Turkey. ebruy@hacettepe.edu.tr
J Clin Pharm Ther ; 31(1): 49-55, 2006 Feb.
Article em En | MEDLINE | ID: mdl-16476120
ABSTRACT

BACKGROUND:

The effects of the macrolides cannot be ascribed to their antibacterial action alone. Their immunoregulatory and anti-inflammatory functions are significant too. They are frequently used in the treatment of diffuse panbronchiolitis and cystic fibrosis (CF).

AIM:

To evaluate the effects of a macrolide antibiotic [clarithromycin (CAM)] on the process of inflammation [by measuring IL-8, TNF-alpha, IL-10 levels and cell profiles in bronchoalveolar lavage (BAL) fluid], pulmonary function and sputum production in children with steady-state bronchiectasis, secondary to causes other than CF or primary immunodeficiencies.

METHODS:

Seventeen patients randomized to the treatment group received CAM and supportive therapies for 3 months and 17 patients in the control group were given supportive therapies only.

RESULTS:

Compared with the control group, the treatment group showed a significant decrease in IL-8 levels, total cell count, neutrophil ratios in BAL fluid and daily sputum production at the end of the third month. There was also a significant increase in the treatment group's BAL fluid macrophage ratios. The differences in pulmonary function test parameters were not significant.

CONCLUSION:

Use of CAM in children with steady-state bronchiectasis results in laboratory improvement by reducing the inflammatory processes in the lungs. No corresponding clinical improvement could be shown but although this is possible with long-term use, trial validation is necessary.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bronquiectasia / Claritromicina / Antibacterianos Tipo de estudo: Clinical_trials Limite: Adolescent / Child / Female / Humans / Male Idioma: En Ano de publicação: 2006 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bronquiectasia / Claritromicina / Antibacterianos Tipo de estudo: Clinical_trials Limite: Adolescent / Child / Female / Humans / Male Idioma: En Ano de publicação: 2006 Tipo de documento: Article