Effect of botulinum toxin antral injection on gastric emptying and weight reduction in obese patients: a pilot study.
Aliment Pharmacol Ther
; 23(5): 675-80, 2006 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-16480407
ABSTRACT
BACKGROUND:
A potential approach to the treatment of morbid obesity is reduction of gastric emptying to achieve satiety. Botulinum toxin A (Btx-A) is a long-acting inhibitor of acetylcholine-mediated peristalsis, which is mainly responsible for gastric motility.AIM:
To investigate whether botulinum toxin A, injected in the antrum of obese patients, delays gastric emptying.METHODS:
In a double_blind study, 18 healthy obese subjects (body mass index >30) were randomized into three groups (BTX133, BTX200 and Saline); they received Btx-A133U, Btx-A200U, or saline under endoscopic control. Gastric emptying was tested by scintigraphy before and 10 days after treatment. Body weight variations and appetite sensation were recorded after 5 weeks.RESULTS:
Fourteen patients completed the study. The botulinum toxin A-treated groups showed weight reduction, which was not statistically significant. The effects on gastric emptying were variable. Most of the botulinum toxin A treated patients reported a reduced appetite.CONCLUSION:
This pilot clinical trial suggests potential activity of botulinum toxin A for the manipulation of appetite.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Redução de Peso
/
Toxinas Botulínicas Tipo A
/
Esvaziamento Gástrico
/
Fármacos Neuromusculares
/
Obesidade
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article