Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates.
Nat Med
; 12(3): 301-3, 2006 Mar.
Article
em En
| MEDLINE
| ID: mdl-16491083
ABSTRACT
Cell-based diabetes therapy requires an abundant cell source. Here, we report reversal of diabetes for more than 100 d in cynomolgus macaques after intraportal transplantation of cultured islets from genetically unmodified pigs without Gal-specific antibody manipulation. Immunotherapy with CD25-specific and CD154-specific monoclonal antibodies, FTY720 (or tacrolimus), everolimus and leflunomide suppressed indirect activation of T cells, elicitation of non-Gal pig-specific IgG antibody, intragraft expression of proinflammatory cytokines and invasion of infiltrating mononuclear cells into islets.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Suínos
/
Transplante Heterólogo
/
Transplante das Ilhotas Pancreáticas
/
Terapia de Imunossupressão
/
Diabetes Mellitus Experimental
/
Macaca
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article