Lower heart rate variability is associated with higher serum high-sensitivity C-reactive protein concentration in healthy individuals aged 46 years or more.
Int J Cardiol
; 107(3): 333-7, 2006 Mar 08.
Article
em En
| MEDLINE
| ID: mdl-16503254
ABSTRACT
BACKGROUND:
To test the hypothesis of an association between cardiac autonomic activity evaluated by heart rate variability and systemic inflammatory markers such as C-reactive protein, we studied the correlation of the indices of heart rate variability relative to serum high-sensitivity C-reactive protein (hs-CRP) in a healthy Brazilian population.METHODS:
Four hundred twenty-one healthy individuals aged 15-82 years (mean 40.4 years), 184 men (43.7%) and 237 women (56.3%) were enrolled between July 1998 and July 2001. The relationship between the log-transformed indices of the heart rate variability and the serum concentration of hs-CRP were analyzed stratified by age tertile using the Spearman correlation coefficient and multiple linear regression.RESULTS:
The log standard deviation of all normal sinus RR intervals over 24 h (SDNN) (r = -0.801; p = 0.024) was independently correlated with log hs-CRP in the individuals with age in the oldest tertile (> or = 46 years). In addition, the body mass index (BMI) was independently correlated with hs-CRP in all of the age groups.CONCLUSIONS:
In the healthy subjects aged 46 years or more the lower heart rate variability correlated with higher concentration of hs-CRP.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteína C-Reativa
/
Frequência Cardíaca
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article