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Isolation, identification, and partial cDNA cloning of genomic RNA of jaagsiekte retrovirus, the etiological agent of sheep pulmonary adenomatosis.
York, D F; Vigne, R; Verwoerd, D W; Querat, G.
Afiliação
  • York DF; Laboratoire de Virologie, Faculté de Médecine Nord, Marseille, France.
J Virol ; 65(9): 5061-7, 1991 Sep.
Article em En | MEDLINE | ID: mdl-1651422
The genome of the jaagsiekte (JS) retrovirus (JSRV), the etiological agent of sheep pulmonary adenomatosis (jaagsiekte), has been identified, isolated, and partly cloned. The JSRV genome is ca. 8.7 kb long. cDNA of the genomic RNA was synthesized and cloned. A clone, JS 46.1, was isolated and characterized. It has an insert of 2.1 kb which hybridizes to the same 8.7-kb RNA in all the JSRV-infected sheep lung washes tested but does not hybridize to maedi-visna virus, a sheep lentivirus often found coinfecting JSRV-infected lungs. Comparison of the amino acid sequence encoded by JS 46.1 with those encoded by other retroviruses revealed that JSRV has homology to the type D and B oncoviruses and to human endogenous retrovirus.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adenomatose Pulmonar Ovina / Retroviridae / RNA Viral / Produtos do Gene env Tipo de estudo: Diagnostic_studies / Etiology_studies Limite: Animals Idioma: En Ano de publicação: 1991 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adenomatose Pulmonar Ovina / Retroviridae / RNA Viral / Produtos do Gene env Tipo de estudo: Diagnostic_studies / Etiology_studies Limite: Animals Idioma: En Ano de publicação: 1991 Tipo de documento: Article