A specific, high-affinity, limited-capacity estrogen binding component in the cytosol of human fetal pituitary and brain tissues.
J Clin Endocrinol Metab
; 40(5): 909-12, 1975 May.
Article
em En
| MEDLINE
| ID: mdl-165222
ABSTRACT
A macromoleclar component which binds 3H-estradiol with high affinity and limited capacity is present in the 150,000 x g supernatant fraction of pituitary, hypothalamus, cortex, and limbic system of both male and female human fetwses. 17 beta-estradiol and 17alpha-ethinylestradiol effectively compete with 3H-estradiol for binding sites while testosterone, dihydrotes-tosterone, and cortisol do not. The binding component is different from sexhormone-binding-globulin. It is present in these tissues in relatively large amounts and it is tentatively identified as an estrogen recptor.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hipófise
/
Encéfalo
/
Receptores de Superfície Celular
/
Estradiol
Limite:
Female
/
Humans
/
Male
/
Pregnancy
Idioma:
En
Ano de publicação:
1975
Tipo de documento:
Article