Stereospecific backbone methylation of pyrrolidine-amide oligonucleotide mimics (POM).
Chem Commun (Camb)
; (13): 1436-8, 2006 Apr 07.
Article
em En
| MEDLINE
| ID: mdl-16550292
ABSTRACT
The introduction of (7'S)-methyl groups into the backbone of pyrrolidine-amide oligonucleotide mimics (POM) does not interfere with high affinity recognition of complementary nucleic acids, whereas (7'R)-methylation disrupts hybridisation significantly.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligonucleotídeos
/
Pirrolidinas
/
Materiais Biomiméticos
/
Amidas
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article