Interleukin-10, T-lymphocytes, and cardiac output in children after ventricular septal defect repair: a pilot study.
Intensive Care Med
; 32(5): 780-4, 2006 May.
Article
em En
| MEDLINE
| ID: mdl-16550368
ABSTRACT
OBJECTIVE:
To evaluate the acute inflammatory response and cardiac output in children after surgery for ventricular septal defect. DESIGN ANDSETTING:
Prospective, observational study in a level III multidisciplinary neonatal and pediatric intensive care unit. PATIENTS Ten children undergoing open-heart surgery for ventricular septal defect.INTERVENTIONS:
All children received methylprednisolone (30 mg/kg) in cardiopulmonary bypass (CPB) prime. MEASUREMENTS ANDRESULTS:
Before and after cardiopulmonary bypass, plasma interleukin-10 and tumor necrosis factor alpha were measured by enzyme-linked immunosorbent assay, and lymphocyte subsets in peripheral blood by flow cytometry. Relative values (post-/pre-CPB) of interleukin-10 and tumor necrosis factor alpha were calculated. The cardiac index (CI) was measured continuously beat-to-beat by a pulse contour analysis (PiCCO). Children above the cutoff value (median cardiac index value 3.0 l min(-1) m(-2)) were designated as the normal CI group and those below this value as the low CI group. In the normal CI group the relative values of interleukin-10 remained almost seven times higher than pre-CPB values at 24 h while in the low CI group they decreased almost to pre-CPB values. Furthermore, the normal CI group, but not the low CI group, exhibited more than threefold decrease in T-lymphocytes (lymphocyte T-cells, T-helper cells, and cytotoxic T-cells) 24 h after CPB.CONCLUSIONS:
Children operated on for ventricular septal defect developed either a normal or low CI. The higher relative values of interleukin-10 and lower counts of lymphocyte T-cells, T-helper and cytotoxic T-cells differentiated the normal CI group from the low CI group at 24 h after cardiopulmonary bypass.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Débito Cardíaco
/
Linfócitos T
/
Interleucina-10
/
Síndrome de Resposta Inflamatória Sistêmica
/
Comunicação Interventricular
Tipo de estudo:
Observational_studies
Limite:
Female
/
Humans
/
Infant
/
Male
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article