[Progression of lipopolysaccharide signal pathway].
Zhong Nan Da Xue Xue Bao Yi Xue Ban
; 31(1): 141-5, 2006 Feb.
Article
em Zh
| MEDLINE
| ID: mdl-16562697
ABSTRACT
Lipopolysaccharide (LPS) is the major constituents of the outer membrane of Gram-negative bacteria. LPS recognition and signal transmission are key events in the host defense reaction towards Gram-negative bacteria and are associated with many disorders. Multiple signaling pathways are involved in the response to LPS. With the help of LPS-binding protein and CD14, TLR4 binds with LPS, then recruits myeloid differentiation factor 88 and IL-1 receptor-associated kinase, and further phosphorylates and activates TNF receptor associated factor 6 (TRAF6). The activated TRAF6 leads to the activation of transcription factor NF-kappaB and MAP kinase's pathways that involves in LPS-induced cellular responses and the production of proinflammatory cytokines such as TNF-alpha, IL-6 and IL8.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Lipopolissacarídeos
/
Bactérias Gram-Negativas
Idioma:
Zh
Ano de publicação:
2006
Tipo de documento:
Article