Cortical excitatory amino acid release and cell function during hypotension in near-term born lambs.
Biol Neonate
; 90(2): 128-34, 2006.
Article
em En
| MEDLINE
| ID: mdl-16582537
ABSTRACT
BACKGROUND:
Energy failure due to insufficient cerebral O2-supply leads to excess accumulation of calcium ions in presynaptic neurons, followed by excess release of excitatory amino acids, which are potent neurotoxins, into the synaptic cleft.AIM:
To investigate whether electrocortical brain activity (ECBA) can provide an adequate measure for excitatory amino acid release due to hemorrhagic hypotension.METHODS:
Ten near-term lambs were delivered at 127 days of gestation (term 147 days). After a stabilization period, hypotension was induced by stepwise withdrawal of blood. Cerebral microdialysis was used to measure the concentrations of glutamate and aspartate.RESULTS:
During hypotension, mean arterial blood pressure, cerebral O2-supply and ECBA decreased and the extracellular concentration of glutamate increased significantly. ECBA was significantly related to glutamate (R2 0.67, p < 0.001) and aspartate (R2 0.57, p < 0.001) concentrations.CONCLUSION:
The extracellular release of glutamate and aspartate in the cerebral cortex increases after hemorrhagic hypotension in near-term born lambs. The extracellular overflow of glutamate and aspartate were significantly inversely related to ECBA.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Córtex Cerebral
/
Aminoácidos Excitatórios
/
Hipotensão Intracraniana
Limite:
Animals
/
Pregnancy
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article