Is free/total PSA predictive of pathological stage and Gleason score in patients with prostate cancer and serum PSA Pepe, Pietro; Panella, Paolo; Pietropaolo, Francesco; Pennisi, Michele; Allegro, Rosalinda; Aragona, Francesco. Afiliação Pepe P; Urology Unit, Cannizzaro Hospital, Catania, and Department of Internal Medicine, Cardiovascular and Nephro-Urological Diseases, University of Palermo, Italy. Urol Int ; 76(3): 232-5, 2006. Article em En | MEDLINE | ID: mdl-16601385

ABSTRACT

INTRODUCTION: To evaluate whether percent free prostate-specific antigen (%-fPSA) could be predictive of pathological stage and Gleason score in patients with prostate cancer (PCa) and serum PSA of 10 ng/ml or less. MATERIALS AND METHODS: In 100 patients with total PSAwho underwent radical retropubic prostatectomy as primary treatment of PCa, %-fPSA levels in organ-confined vs. non-organ-confined PCa and in patients with Gleason score7 were compared.

RESULTS:

32 patients had an organ-confined and 68 a locally advanced PCa. Median %-fPSA level was 15%; Gleasonscore was <7 in 49 patients, equal to 7 in 40 and >7 in 11. Median %-fPSA levels in PCa with Gleason score7 was 14, 15.5 and 15%, respectively. Multiple logistic regression analysis did not show any correlation between %-fPSA in organ-confined vs. non-organ-confined PCa (p=0.4991) either between Gleason score<7 vs. equal to 7 (p=0.588) or >7 (p=0.547).

CONCLUSIONS:

%-fPSA cut-off does not seem to be useful for preoperative staging of patients with PCa and serum PSA