Mechanisms of liver injury. III. Oxidative stress in the pathogenesis of hepatitis C virus.
Am J Physiol Gastrointest Liver Physiol
; 290(5): G847-51, 2006 May.
Article
em En
| MEDLINE
| ID: mdl-16603728
ABSTRACT
Hepatitis C virus (HCV) is a major cause of viral hepatitis that can progress to hepatic fibrosis, steatosis, hepatocellular carcinoma, and liver failure. HCV infection is characterized by a systemic oxidative stress that is most likely caused by a combination of chronic inflammation, iron overload, liver damage, and proteins encoded by HCV. The increased generation of reactive oxygen and nitrogen species, together with the decreased antioxidant defense, promotes the development and progression of hepatic and extrahepatic complications of HCV infection. This review discusses the possible mechanisms of HCV-induced oxidative stress and its role in HCV pathogenesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hepatite C
/
Hepacivirus
/
Estresse Oxidativo
/
Fígado
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article