Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
J Med Chem
; 49(8): 2363-6, 2006 Apr 20.
Article
em En
| MEDLINE
| ID: mdl-16610779
Casein kinase 2 (CK2) is a ubiquitous, essential, and highly pleiotropic protein kinase whose abnormally high constitutive activity is suspected to underlie its pathogenic potential in neoplasia and other diseases. Using a virtual screening approach, we have identified the ellagic acid, a naturally occurring tannic acid derivative, as a novel potent CK2 inhibitor. At present, ellagic acid represents the most potent known CK2 inhibitor (K(i) = 20 nM).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Caseína Quinase II
/
Ácido Elágico
/
Inibidores Enzimáticos
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article